Objective and Clientele:

This course is an introduction to nuclear magnetic resonance for students who seek expertise in the fundamentals of nuclear magnetic resonance. Lectures cover theory, instrumentation, and applications in the physical sciences, engineering, and health-related fields.

Prerequisites:

Undergraduate physics (phys. 122 or equivalent)

Course Outline:

Overview

Precessing Tops and the Faraday Detector, The Zeeman Interaction, The Chemical Shift Interaction, Magnetic Resonance, Coherence, Relaxation, Inhomogeneous magnetic fields and T₂^∗

The Bloch Equations

Free Precession, RF Pulses, Bloch Decay Experiment.

The Fourier Transform

Absorption and Dispersion mode lineshapes, Phase Corrections.

Limitations of the Bloch Equations

Equations Dipolar Couplings, J Couplings, Nuclear Electric Quadrupole Couplings, Spin Decoupling.

Inside the NMR Spectrometer

Magnetic field homogeneity, shimming, NMR probe design, Signal averaging.

Measuring Relaxation Times

Saturation Recovery, Inversion Recovery, Spin Echo, Echo Train Acquisition.

Coherence Transfer Pathways

Measuring Translational Diffusion Coefficients

Interpreting Relaxation Times

Time correlation and Spectral Density Functions, Relaxation via Dipolar Couplings, Steady- State Overhauser Effect, Quadrupolar Relaxation, Nuclear Shielding Relaxation.

Measuring Chemical Exchange

Modified Bloch Equations.

Multi-dimensional NMR in liquids

2D Exchange, 2D NOESY, transient nOe’s, COSY, ROESY, HSQC, TOCSY, HMQC, HMBC, INEPT, INADEQUATE, etc...

Magnetic Resonance Imaging

Basic principles, k-space, Echo-Planar Imaging.

NMR in the Solid State

Single crystals, Polycrystalline Solids, Magic-Angle Spinning, Cross-Polarization, Spinning Sidebands.

All students with documented disabilities, who need accommodations, should see the instructor privately to schedule an appointment as early in the quarter as possible. If your disability requires materials in alternative format, please contact the Office for Disability Services at 292-3307, Room 150 Pomerene Hall.

ACADEMIC MISCONDUCT

Any material submitted in Chem. 824 must represent your own work. Apparent violations of this standard will be referred to the University Committee of Academic Misconduct (COAM) as required by Faculty Rules. Please read the attached statement on Standards of Academic Conduct carefully. See the URL: http://oaa.osu.edu/coam/home.html for further information about the Student Code of Conduct.